Application

Polyguanylic acid potassium salt has been used:as a ligand for surface neuropilin-1 (NRP1) for internalization studiesfor intercalation studies with trisubstituted and disubstituted triazole-linked phenyl derivatives CL41, CL42 and CL2r50 using voltammetry methodas a synthetic polynucleotide for agarose gel electrophoresis analysis

Polyguanylic acid (PolyG) is used to study the effects of ionizing radiation on formation and stability of G-quadruplex structures and as a target molecule for physicochemical studies of electronic excitation (vibrational spectra) of guanosine.

Biochem/physiol Actions

Polyguanylic acid acts as a ligand for scavenger receptor and reduces the surface expression neuropilin-1 in endothelial cells.

General description

Polyguanylic acid takes up a four-stranded helical structure. It is synthetically produced in Thermus thermophilus from guanosine diphosphate (GDP) and its synthesis is catalyzed by the enzyme polynucleotide phosphorylase.

Packaging

5 mg in glass bottle

25 mg in poly bottle

Preparation Note

Prepared from GDP using polynucleotide phosphorylase